Chapter 4 Life-long stability of neurons: a century of research on neurogenesis, neuronal death and neuron quantification in adult CNS

摘要: Abstract In this chapter we provide an extensive review of 100 years research on the stability neurons in mammalian brain, with special emphasis humans. Although Cajal formulated Neuronal Doctrine, he was wrong his beliefs that adult neurogenesis did not occur and are dying throughout life. These two became accepted “common knowledge” have shaped much neuroscience provided basis for clinical treatment age-related brain diseases. review, consider from a historical evolutionary perspective. It is concluded, while factor dynamics dentate gyrus olfactory bulb, it probably major during life-span most areas. Likewise, acceptance neuronal death as explanation normal senility challenged evidence collected over last fifty years. Much problem changing common belief inadequacies counting methods. discuss detail implications recent improvements quantification. We conclude: First, atrophy functional deterioration existing could be slowed down, or even reversed by various pharmacological interventions. Second, cases degeneration aging pathology principle may avoided. Third, loss myelin white matter more frequent important than limited aging.