Erythromycin treatment suppresses myocardial injury in autoimmune myocarditis in rats via suppression of superoxide production.

摘要: Abstract Background Recent evidence suggests that erythromycin (EM), a major macrolide antibiotic, has many biological functions in addition to the anti-bacterial actions, including anti-inflammatory and free radical scavenging actions. However, effects of drug upon inflammatory myocardial diseases are unknown. We tested hypothesis EM ameliorates experimental autoimmune myocarditis rats attributing suppression superoxide production. Methods administered EM, 3.3mg/kg/day 33mg/kg/day, intraperitoneally for 3weeks, with (EAM) produced by immunization porcine myosin. Results treatment reduced severity compared untreated group dose-dependent manner comparing heart weight/body weight ratio, pathologic scores, macrophage, CD4 + , CD8 infiltrations. Echocardiographic study showed increased left ventricular posterior wall thickness inflammation was treatment. Myocardial production, determined dihydroethidium staining, significantly Western blotting expression interleukin-1β groups. The vivo dorsal air pouch model suppressed leukocyte chemotaxis manner. Conclusion Irrespective well-known classic attenuated EAM not only action but