Amplification and the clinical significance of circulating cell-free DNA of PVT1 in breast cancer.
作者： Xujing Li , Weijuan Chen , Hui Wang , Qun Wei , Xiaodi Ding
DOI: 10.3892/OR.2017.5650
关键词:
摘要: Abstract Duplication in the chromosome 8q24 region is a frequent occurrence carcinomas. The PVT1 oncogene (PVT1), long non-coding RNA, found this locus. amplification event cancers, such as lymphomas, serous ovarian, colorectal and breast cancers. Ectopic expression related with reduced survival duration cancer patients. present study, we proved that markedly augmented tissues compared adjacent non-tumorous tissues. Thus, an independent prognostic factor for of Furthermore, pivotal regulating p21 expression. In addition, detected DNA serum circulating significantly increased Compared main form PVT1-derived segment. These relevant findings collectively demonstrate plays role possible target novel therapies. detection fragments may be convenient means to predict prognosis
sci-hub.se 参考文章(22)
Guang-Yu Wang, Yuan-Yuan Zhu, Yan-Qiao Zhang, The functional role of long non-coding RNA in digestive system carcinomas Bulletin Du Cancer. ,vol. 101, pp. 27- 31 ,(2014) , 10.1684/BDC.2014.2023
Taija M af Hällström, Maija Puhka, Olli Kallioniemi, Circulating tumor DNA in early-stage breast cancer: personalized biomarkers for occult metastatic disease and risk of relapse? Embo Molecular Medicine. ,vol. 7, pp. 994- 995 ,(2015) , 10.15252/EMMM.201505332
Cathy Eng, Circulating DNA biomarkers: a primer for metastatic colorectal cancer? The Lancet Oncology. ,vol. 16, pp. 878- 879 ,(2015) , 10.1016/S1470-2045(15)00061-3
Heidi Schwarzenbach, Klaus Pantel, Circulating DNA as biomarker in breast cancer Breast Cancer Research. ,vol. 17, pp. 136- 136 ,(2015) , 10.1186/S13058-015-0645-5
Philipp G. Maass, Friedrich C. Luft, Sylvia Bähring, Long non-coding RNA in health and disease Journal of Molecular Medicine. ,vol. 92, pp. 337- 346 ,(2014) , 10.1007/S00109-014-1131-8
Xiaodong Song, Guohong Cao, Lili Jing, Shengcui Lin, Xiaozhi Wang, Jinjin Zhang, Meirong Wang, Weili Liu, Changjun Lv, Analysing the relationship between lncRNA and protein-coding gene and the role of lncRNA as ceRNA in pulmonary fibrosis Journal of Cellular and Molecular Medicine. ,vol. 18, pp. 991- 1003 ,(2014) , 10.1111/JCMM.12243
Y Takahashi, G Sawada, J Kurashige, R Uchi, T Matsumura, H Ueo, Y Takano, H Eguchi, T Sudo, K Sugimachi, H Yamamoto, Y Doki, M Mori, K Mimori, Amplification of PVT-1 is involved in poor prognosis via apoptosis inhibition in colorectal cancers British Journal of Cancer. ,vol. 110, pp. 164- 171 ,(2014) , 10.1038/BJC.2013.698
Johnathan M. Lancaster, Holly K. Dressman, Regina S. Whitaker, Laura Havrilesky, Jonathan Gray, Jeffrey R. Marks, Joseph R. Nevins, Andrew Berchuck, Gene expression patterns that characterize advanced stage serous ovarian cancers. Journal of The Society for Gynecologic Investigation. ,vol. 11, pp. 51- 59 ,(2004) , 10.1016/J.JSGI.2003.07.004
C. Mu, P. Jia, Z. Yan, X. Liu, X. Li, H. Liu, Quercetin induces cell cycle G1 arrest through elevating Cdk inhibitors p21 and p27 in human hepatoma cell line (HepG2). Methods and Findings in Experimental and Clinical Pharmacology. ,vol. 29, pp. 179- 183 ,(2007) , 10.1358/MF.2007.29.3.1092095
Mitchell Guttman, Ido Amit, Manuel Garber, Courtney French, Michael F. Lin, David Feldser, Maite Huarte, Or Zuk, Bryce W. Carey, John P. Cassady, Moran N. Cabili, Rudolf Jaenisch, Tarjei S. Mikkelsen, Tyler Jacks, Nir Hacohen, Bradley E. Bernstein, Manolis Kellis, Aviv Regev, John L. Rinn, Eric S. Lander, Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals Nature. ,vol. 458, pp. 223- 227 ,(2009) , 10.1038/NATURE07672