Gene expression patterns that characterize advanced stage serous ovarian cancers.
作者： Johnathan M. Lancaster , Holly K. Dressman , Regina S. Whitaker , Laura Havrilesky , Jonathan Gray
DOI: 10.1016/J.JSGI.2003.07.004
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摘要: Objective:To identify gene expression patterns that characterize advanced stage serous ovarian cancers by using microarray analysis.Methods:Using genome-wide analysis, we compared a series of 31 (III or IV) from patients who survived either less than 2 years more 7 with three normal epithelial samples. Array findings were validated analysis the insulin-like growth factor binding protein (IGFBP2) and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) genes quantitative real-time polymerase chain reaction (QRT-PCR).Results:Hierarchical clustering identified distinguished cancer epithelium. We also distinguish on basis patient survival. These include many associated immune function. Expression IGFBP2 TRAIL measured array QRT-PCR demo...
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