The p53 tumor suppressor gene frequently is altered in gynecologic cancers.

摘要: Mutation of the p53 tumor suppressor gene, often accompanied by overexpression mutant protein, is most frequent molecular genetic event described thus far in human cancers. In adenocarcinomas ovary and endometrium, seen approximately 10% to 15% early 40% 50% advanced Similar many other types cancers, ovarian endometrial cancers that overexpress protein contain mutations conserved regions gene. These are predominantly transitions, which suggests they arise spontaneously rather than being caused carcinogen exposure. Alteration gene does not appear be a feature hyperplasias or benign borderline tumors. Although mutation rarely occur cervix, vulva, vagina, it has been shown papillomavirus E6 oncoproteins bind inactivate protein. Studies have begun provide insight into pathogenesis gynecologic