The Role of CXCR3 and Its Chemokine Ligands in Skin Disease and Cancer.
作者： Paula T. Kuo , Zhen Zeng , Nazhifah Salim , Stephen Mattarollo , James W. Wells
关键词:
摘要: Chemokines and their receptors play an important role in the recruitment, activation differentiation of immune cells. The chemokine receptor, CXCR3, its ligands, CXCL9, CXCL10, CXCL11 are key chemoattractants during interferon-induced inflammatory responses. Inflammation skin resulting from infections or autoimmune disease drives expression CXCL9/10/11 subsequent recruitment effector, CXCR3+ T cells circulation. relative contributions different CXCR3 chemokines three variant isoforms (CXCR3A, CXCR3B, CXCR3alt) to process human requires further investigation. In cancers, receptor can a dual whereby on tumor lead cancer metastasis systemic sites while frequently promote anti-tumor This review will discuss biology associated ligands with particular emphasis inflammation carcinogenesis.
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