The involvement of taurine in the action mechanism of sodium valproate (VPA) in the treatment of epilepsy.

摘要: Abstract Several lines of evidence have shown that sodium valproate (VPA) mechanism action in the therapy epilepsy is based on phenomena its interaction with neurotransmitters (GABA), receptor sites and ion channels (1). However, there no conclusive to show extent VPA interactions other brain. Based this fact, taurine (an amino acid 'neurotransmitter') found distributed brain visual system may probably be involved drug VPA. The application experimental human started over thirty years ago (2,3) it has been known possess some mild anticonvulsant activity both humans animal models (4). This review, therefore, will attempt draw together all available information involvement possible association suppressing epileptic seizures. Structural physiological distribution discussed. Its cited. neurotransmitter candidacy, ocular pathology, modulatory dealt relation epilepsy.