Phenotypic Characterization of a Genetically Diverse Panel of Mice for Behavioral Despair and Anxiety
作者： Brooke H. Miller , Laura E. Schultz , Anisha Gulati , Andrew I. Su , Mathew T. Pletcher
DOI: 10.1371/JOURNAL.PONE.0014458
关键词:
摘要: Background Animal models of human behavioral endophenotypes, such as the Tail Suspension Test (TST) and Open Field assay (OF), have proven to be essential tools in revealing genetics mechanisms psychiatric diseases. As disorders they model, measurements generated these assays are significantly impacted by genetic background animals tested. In order better understand strain-dependent phenotypic variability endemic this type work, inform future studies that rely on data models, we phenotyped 33 inbred mouse strains for immobility TST, a model despair, activity OF, general anxiety locomotor activity.
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