Adult height in girls with idiopathic true precocious puberty

摘要: GnRH analogs are used to suppress pituitary-gonadal activity in children with true precocious puberty. The indications for therapy this situation not established, as some girls have a slow evolutive form, and the capacity of preserve adult height has been evaluated. This study analyzes growth heights 2 groups idiopathic puberty, 1 predicted 155 cm or less (group 1, 19 cases) other more than 2, 15 cases). Group patients were treated long-acting analog (D-Trp6-GnRH), group followed without therapy. showed greater clinical signs estrogenization, vaginal maturation index (P < 0.03), plasma estradiol 0.0004), ratio LH/FSH peaks 0.01) at initial evaluation did 2. mean target similar (difference, 0.9 cm). In (159 +/- 1.1 cm) was before (152 1.4 cm; P 0.0001). difference between (mean, 6.5 correlated positively bone age advance 0.01), negatively 0.05), 0.001) (162 (162.5 Adult conclusion, puberty poor prediction who achieve an comparable their height. However, lack effect on onset preservation potential forms suggest that these might require immediate Careful follow-up may be better way evaluating natural course.