Physicochemical properties and chromatographic behavior of a homologous series of methotrexate-α-γ-dialkyl ester prodrugs
作者： James J. Fort , Ashim K. Mitra
DOI: 10.1016/0378-5173(87)90230-4
关键词:
摘要: … A high-performance liquid chromatographic (HPLC) method for … The effect of chain length and mobile phase composition on … that prodrugs of MTX having very long ester chain lengths (n …
sci-hub.se 参考文章(28)
Corwin Herman Hansch, Albert Leo, Substituent constants for correlation analysis in chemistry and biology Published in <b>1979</b> in New York NY) by Wiley. ,(1979)
Carl Robert Noller, Chemistry of Organic Compounds ,(1951)
Lloyd R. Snyder, John W. Dolan, Joseph J. Kirkland, Introduction to modern liquid chromatography ,(1979)
M Poe, Acidic dissociation constants of folic acid, dihydrofolic acid, and methotrexate. Journal of Biological Chemistry. ,vol. 252, pp. 3724- 3728 ,(1977) , 10.1016/S0021-9258(17)40312-7
PHILIP S. SCHEIN, Immunosuppressive and Cytotoxic Chemotherapy: Long-Term Complications Annals of Internal Medicine. ,vol. 82, pp. 84- 95 ,(1975) , 10.7326/0003-4819-82-1-84
T.L. Hafkenscheid, E. Tomlinson, Correlations between alkane/water and octan-1-ol/ water distribution coefficients and isocratic reversed-phase liquid chromatographic capacity factors of acids, bases and neutrals International Journal of Pharmaceutics. ,vol. 16, pp. 225- 239 ,(1983) , 10.1016/0378-5173(83)90059-5
A. Rosowsky, Methotrexate analogs. 2. A facile method of preparation of lipophilic derivatives of methotrexate and 3',5'-dichloromethotrexate by direct esterification. Journal of Medicinal Chemistry. ,vol. 16, pp. 1190- 1193 ,(1973) , 10.1021/JM00268A029
Gerald D. Weinstein, Methotrexate for Psoriasis Archives of Dermatology. ,vol. 103, pp. 33- 38 ,(1971) , 10.1001/ARCHDERM.1971.04000130035004
Barry L. Karger, J.Russel Gant, Arleigh Martkopf, Paul H. Weiner, Hydrophobic effects in reversed-phase liquid chromatography Journal of Chromatography A. ,vol. 128, pp. 65- 78 ,(1976) , 10.1016/S0021-9673(00)84032-7
Richard H. Guy, Donald H. Honda, Solute transport resistance at the octanol-water interface International Journal of Pharmaceutics. ,vol. 19, pp. 129- 137 ,(1984) , 10.1016/0378-5173(84)90155-8