Advances in herpes simplex virus antiviral therapies
作者： Sreeman K Mamidyala , Steven M Firestine
DOI: 10.1517/13543776.16.11.1463
关键词:
摘要: Herpes simplex viruses (HSV) are responsible for usually non-life threatening infections of the oral, ocular and genital regions. The infect a significant percentage US population almost two million new cases reported each year. Present medicinal agents that treat HSV target catalytic activity virally encoded DNA polymerase. Although these have been shown to be safe efficacious, many possess limited oral bioavailability, must given early in disease process maximum effect resistance is problem immunocompromised individuals. Thus, there need continued development anti-HSV agents. This review discusses published medical patent literature during 2004 – 2006 highlights recent advances nucleoside non-nucleoside inhibitors polymerase, helicase–primase complex, viral entry compounds no ...
uq.edu.au
core.ac.uk参考文章(88)
Kazuhiro Haraguchi, Haruhiko Takahashi, Hiromichi Tanaka, Hiroyuki Hayakawa, Noriyuki Ashida, Takao Nitanda, Masanori Baba, Synthesis and antiviral activities of 1'-carbon-substituted 4'-thiothymidines. Bioorganic & Medicinal Chemistry. ,vol. 12, pp. 5309- 5316 ,(2004) , 10.1016/J.BMC.2004.07.057
Nobuko Mibu, Kazumi Yokomizo, Masaru Uyeda, Kunihiro Sumoto, Synthesis and Antiviral Activities of Some 4,4′-Dihydroxytriphenylmethanes. ChemInform. ,vol. 35, ,(2004) , 10.1002/CHIN.200416210
Antonio Procopio, Stefano Alcaro, Antonio De Nino, Loredana Maiuolo, Francesco Ortuso, Giovanni Sindona, New conformationally locked bicyclic N,O-nucleoside analogues of antiviral drugs. Bioorganic & Medicinal Chemistry Letters. ,vol. 15, pp. 545- 550 ,(2005) , 10.1016/J.BMCL.2004.11.048
Mara RP De Oliveira, Thatyana R Alves, Angelo C Pinto, Helena de S Pereira, Luiz R Leão‐Ferreira, Nissin Moussatché, Izabel Christina de PP Frugulhetti, Vitor F Ferreira, Maria Cecilia BV de Souza, None, Synthesis and antiviral activities of new pyrazolo[4,3-c]quinolin-3-ones and their ribonucleoside derivatives Nucleosides, Nucleotides & Nucleic Acids. ,vol. 23, pp. 735- 748 ,(2004) , 10.1081/NCN-120038009
B. Gabrielsen, J. J. Kirsi, C. D. Kwong, D. A. Carter, C. A. Krauth, L. K. Hanna, J. W. Huggins, T. P. Monath, D. F. Kefauver, H. A. Blough, J. T. Rankin, C. M. Bartz, J. H. Huffman, D. F. Smee, R. W. Sidwell, W. M. Shannon, J. A. Secrist, In vitro and in vivo antiviral (RNA) evaluation of orotidine 5'-monophosphate decarboxylase inhibitors and analogues including 6-azauridine-5'-(ethyl methoxyalaninyl) phosphate (a 5'-monophosphate prodrug) Antiviral Chemistry & Chemotherapy. ,vol. 5, pp. 209- 220 ,(1994) , 10.1177/095632029400500402
Douglas T. Fleming, Geraldine M. McQuillan, Robert E. Johnson, André J. Nahmias, Sevgi O. Aral, Francis K. Lee, Michael E. St. Louis, Herpes Simplex Virus Type 2 in the United States, 1976 to 1994 The New England Journal of Medicine. ,vol. 337, pp. 1105- 1111 ,(1997) , 10.1056/NEJM199710163371601
Cutaneous Resistance to Viral Infections CRC Press. pp. 33- 46 ,(2002) , 10.1201/B14016-5
Jerzy Boryski, Bozenna Golankiewicz, Erik De Clercq, Synthesis and antiviral activity of 3-substituted derivatives of 3,9-dihydro-9-oxo-5H-imidazo[1,2-a]purines, tricyclic analogues of acyclovir and ganciclovir. Journal of Medicinal Chemistry. ,vol. 34, pp. 2380- 2383 ,(1991) , 10.1021/JM00112A010
Michael R. Detty, Scott L. Gibson, Stephen J. Wagner, Current clinical and preclinical photosensitizers for use in photodynamic therapy Journal of Medicinal Chemistry. ,vol. 47, pp. 3897- 3915 ,(2004) , 10.1021/JM040074B
Michael R. Dyson, Paul L. Coe, Richard T. Walker, The synthesis and antiviral activity of some 4'-thio-2'-deoxy nucleoside analogues. Journal of Medicinal Chemistry. ,vol. 34, pp. 2782- 2786 ,(1991) , 10.1021/JM00113A016