Isolation of epi-oleanolic acid from Korean mistletoe and its apoptosis-lnducing activity in tumor cells.
作者： Myung Ju Jung , Yung Choon Yoo , Kyung Bok Lee , Jong Bae Kim , Kyung Sik Song
DOI: 10.1007/BF02980176
关键词:
摘要: A triterpene was isolated as a cytotoxic principle from the dichloromethane extract of Korean mistletoe (KM;Viscum album coloratum) by repeated silica gel chromatography and recrystallization. Inin vitro analysis activity using various human murine tumor cell lines, KM highly against these cells. We most active compound, referred to VD-3, KM. The VD-3 shown be less normal cells (murine splenocytes). From identification chemical structure spectral data synthesis, compound proven beepi-oleanolic acid. Tumor treated with showed typical pattern apoptotic death, such apparent morphological changes DNA fragmentation. These results indicate thatepi-oleanolic acid is an important responsible for antitumor
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