Replication and shedding of MERS-CoV in upper respiratory tract of inoculated dromedary camels.

摘要: In 2012, a novel coronavirus associated with severe respiratory disease in humans emerged the Middle East. Epidemiologic investigations identified dromedary camels as likely source of zoonotic transmission East syndrome (MERS-CoV). Here we provide experimental support for reservoir MERS-CoV. We inoculated 3 adult human isolate MERS-CoV and transient, primarily upper tract infection developed each animals. Clinical signs were benign, but shed large quantities virus from tract. detected infectious nasal secretions through 7 days postinoculation, viral RNA up to 35 postinoculation. The pattern shedding propensity may help explain lack systemic illness among naturally infected means efficient camel-to-camel camel-to-human transmission.