Proteins and Their Interacting Partners: An Introduction to Protein-Ligand Binding Site Prediction Methods.

摘要: Elucidating the biological and biochemical roles of proteins, subsequently determining their interacting partners, can be difficult time consuming using in vitro and/or vivo methods, consequently majority newly sequenced proteins will have unknown structures functions. However, silico methods for predicting protein-ligand binding sites protein functions offer an alternative practical solution. The characterisation is essential investigating new functional roles, which impact major research spheres health, food, energy security. In this review we discuss role play 3D modelling sites, along with functionality. addition, describe detail some key prediction approaches that are available, as well discussing Critical Assessment Techniques Protein Structure Prediction (CASP) Continuous Automated Model EvaluatiOn (CAMEO) projects, on developments field. Furthermore, importance function tackling 21st century problems.