Phase II Trial of Imatinib in AIDS-Associated Kaposi's Sarcoma: AIDS Malignancy Consortium Protocol 042
作者： Henry B. Koon , Susan E. Krown , Jeannette Y. Lee , Kord Honda , Suthee Rapisuwon
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摘要: Purpose Kaposi's sarcoma (KS) is a disease of multifocal vascular proliferation that requires infection with KS herpes virus (KSHV/HHV-8). Activation the c-kit and platelet-derived growth factor (PDGF) receptors by autocrine/paracrine mechanisms follows endothelial cell KSHV infection. In pilot study, imatinib, c-kit/PDGF-receptor inhibitor, induced partial regression AIDS-associated (AIDS-KS) in five 10 patients. Patients Methods This multicenter phase II study was designed to estimate response rate imatinib AIDS-KS. Secondary objectives included investigation predictors pharmacokinetics patients on antiretrovirals. received 400 mg/day mouth for up 12 months dose escalation 600 at 3 if their stable. Results Thirty were treated AIDS Malignancy Consortium sites. Ten (33.3%) achieved response, six (20%) had stable disease, seven (23.3%) exhibited pr...
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