Succinylated Chitosan Derivative Has Local Protective Effects on Intestinal Inflammation

摘要: We have previously reported on the anti-inflammatory effects of a water-soluble chitosan derivative, zwitterionic (ZWC). In present study, we hypothesized that orally administered ZWC would provide local in intestinal lumen. indeed showed various vitro models including peritoneal macrophages, engineered THP1 monocytes, and Caco-2 cells. cells, applied before lipopolysaccharide (LPS) challenge was more effective than when it after preventing LPS-induced cell damage. When to mice via drinking water as prophylactic measure, protected animals from 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced colitis, helping them recover body weight, restore gross histological appearance colon, generate FoxP3+ T contrast, did not protect systemic inflammation. These results indicate adm...