摘要: In vivo gene transfer is a useful tool for generating animal models of disease, and validating pathways that are involved in disease. The understanding gained through this technology can provide the information needed to develop new therapeutics specifically targeted at interest. choice vector will depend on tissue cell types be transduced, levels expression needed, duration expression. Recent advances recombinant viral vectors, identification serotypes with different tropism, allow generation wide range models.
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Karim El Bakkouri, Andy Wullaert, Mira Haegman, Karen Heyninck, Rudi Beyaert, Adenoviral Gene Transfer of the NF-κB Inhibitory Protein ABIN-1 Decreases Allergic Airway Inflammation in a Murine Asthma Model Journal of Biological Chemistry. ,vol. 280, pp. 17938- 17944 ,(2005) , 10.1074/JBC.M413588200
Z Y Chen, C Y He, L Meuse, M A Kay, Silencing of episomal transgene expression by plasmid bacterial DNA elements in vivo. Gene Therapy. ,vol. 11, pp. 856- 864 ,(2004) , 10.1038/SJ.GT.3302231
Efren Riu, Dirk Grimm, Zan Huang, Mark A. Kay, Increased Maintenance and Persistence of Transgenes by Excision of Expression Cassettes from Plasmid Sequences In Vivo Human Gene Therapy. ,vol. 16, pp. 558- 570 ,(2005) , 10.1089/HUM.2005.16.558
Guangping Gao, Luk Vandenberghe, James Wilson, New recombinant serotypes of AAV vectors. Current Gene Therapy. ,vol. 5, pp. 285- 297 ,(2005) , 10.2174/1566523054065057
Hiroyuki Nakai, Xiaolin Wu, Sally Fuess, Theresa A. Storm, David Munroe, Eugenio Montini, Shawn M. Burgess, Markus Grompe, Mark A. Kay, Large-Scale Molecular Characterization of Adeno-Associated Virus Vector Integration in Mouse Liver Journal of Virology. ,vol. 79, pp. 3606- 3614 ,(2005) , 10.1128/JVI.79.6.3606-3614.2005
Candace Summerford, Richard Jude Samulski, Membrane-Associated Heparan Sulfate Proteoglycan Is a Receptor for Adeno-Associated Virus Type 2 Virions Journal of Virology. ,vol. 72, pp. 1438- 1445 ,(1998) , 10.1128/JVI.72.2.1438-1445.1998
N J Caplen, Gene Therapy Progress and Prospects. Downregulating gene expression: the impact of RNA interference Gene Therapy. ,vol. 11, pp. 1241- 1248 ,(2004) , 10.1038/SJ.GT.3302324
Vivian Choi, Douglas McCarty, R. Samulski, AAV hybrid serotypes: improved vectors for gene delivery. Current Gene Therapy. ,vol. 5, pp. 299- 310 ,(2005) , 10.2174/1566523054064968
Maria Fe Medina, Gary P Kobinger, John Rux, Mehdi Gasmi, David J Looney, Paul Bates, James M Wilson, Lentiviral vectors pseudotyped with minimal filovirus envelopes increased gene transfer in murine lung Molecular Therapy. ,vol. 8, pp. 777- 789 ,(2003) , 10.1016/J.YMTHE.2003.07.003
Inder M. Verma, Matthew D. Weitzman, GENE THERAPY: Twenty-First Century Medicine Annual Review of Biochemistry. ,vol. 74, pp. 711- 738 ,(2005) , 10.1146/ANNUREV.BIOCHEM.74.050304.091637