Major Signaling Pathways Involved in Breast Cancer

摘要: Breast cancer is the leading cause of cancer-related mortality among women worldwide. Significant advancement has been made recently in delineating cellular processes and signaling pathways involved breast cancer. Cross-communication between different allows cells to identify respond appropriately extracellular environment. Cancer development a gradual complex process resulting from any disruption these that ultimately generates signals defining required biological response. The epidermal growth factor receptor (EGFR) family tyrosine kinases represents both key regulators normal as well critical players variety cancers including aim this book chapter give broad overview signal transduction networks such Ras/Raf/MEK/ERK PI3K/AKT are controlled by EGFR superfamily receptors. elucidation will further provide new insights understanding pathogenesis targeting combat against development, progression, metastasis.