Cross-regulation between FOXA1 and ErbB2 Signaling in Estrogen Receptor-Negative Breast Cancer

摘要: Molecular apocrine is a subtype of estrogen receptor-negative (ER.) breast cancer, which characterized by steroid-response gene signature that includes androgen receptor, FOXA1, and high frequency ErbB2 overexpression. In this study, we demonstrate there strong association between the overexpression FOXA1 in ER- tumors. This has led us to identify cross-regulation network signaling cancer. We present two mechanisms explain molecular cells. one process, genes CREB1 c-Fos regulate transcription, another AP2α regulates expression both ErbB2. Moreover, turn, transcription genes. core shared across cell lines. Importantly, most upregulated (RELB) downregulated (PAK1) are direct targets. Our data suggest acts as dual-function factor repressive function on RELB can be explained recruitment its binding partner corepressor TLE3. It notable group FOXA1-regulated vary lines leading differences functional effects extracellular signal-regulated kinase phosphorylation viability these study demonstrates connects some key pathways