Targeting androgen receptor in estrogen receptor-negative breast cancer.
作者： Min Ni , Yiwen Chen , Elgene Lim , Hallie Wimberly , Shannon T. Bailey
DOI: 10.1016/J.CCR.2011.05.026
关键词:
摘要: Endocrine therapies for breast cancer that target the estrogen receptor (ER) are ineffective in the 25%–30% of cases that are ER negative (ER–). Androgen receptor (AR) is expressed in 60%–70% of breast tumors, independent of ER status. How androgens and AR regulate breast cancer growth remains largely unknown. We find that AR is enriched in ER–breast tumors that overexpress HER2. Through analysis of the AR cistrome and androgen-regulated gene expression in ER–/HER2+ breast cancers we find that AR mediates ligand …
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