18-F-Fluorodeoxyglucose–Positron Emission Tomography Evaluation of Early Metabolic Response During Radiation Therapy for Cervical Cancer

摘要: Purpose To document changes in cervical tumor 18 -F-fluorodeoxyglocose (FDG) uptake during radiation therapy and to correlate those with post-treatment response survival outcome. Methods Materials A total of 36 patients Stage Ib1 IIIb cancer were enrolled an institutional protocol examining the use fluorodeoxyglucose–positron emission tomography (FDG-PET) for brachytherapy treatment planning. As part this study, FDG-PET or PET/computed tomograpy (CT) images obtained before, during, after completion therapy. Tumor metabolic responses assessed qualitatively semi-quantitatively by measurement maximal standardized value (SUV max ). Results Post-treatment study. Of patients, 29 had a complete on PET, 4 partial response, 3 new sites FDG uptake. Six observed therapy, 26 stable increased activity. For median time was 29.5 days (range, 18–43 days). The mean SUV decreased from 11.2 (SD, 6.3; range, 2.1–38.0) pretreatment 2.4 2.7; 0–8.8) mid treatment, 0.5 1.7; 0–8.3) post-treatment. Conclusions During cancer, can be used monitor response. Complete subset patients. Recommendations regarding optimal timing will require further systematic