Reduced Plasma Orexin-A Concentrations are Associated with Cognitive Deficits in Anorexia Nervosa.
作者： Trevor Steward , Gemma Mestre-Bach , Roser Granero , Isabel Sánchez , Nadine Riesco
DOI: 10.1038/S41598-019-44450-6
关键词:
摘要: Orexins/hypocretins are neuropeptides implicated in numerous processes, including food intake and cognition. The role of these peptides the psychopathology anorexia nervosa (AN) remains poorly understood. aim current study was to evaluate associations between plasma orexin-A (OXA) concentrations neuropsychological functioning adult women with AN, a matched control group. Fasting OXA were taken 51 females AN healthy controls. Set-shifting assessed using Wisconsin Card Sorting Test (WCST), whereas decision making measured Iowa Gambling Task (IGT). group exhibited lower levels than HC Lower mean scores obtained on IGT patients. WCST perseverative errors significantly higher compared HC. In both group, negatively correlated non-perseverative errors. Reduced found be associated set-shifting impairments AN. Taking into consideration function orexins promoting arousal cognitive flexibility, future studies should explore whether orexin partly underpins
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