Chronic intermittent hypoxia creates the perfect storm with calamitous consequences for respiratory control.

摘要: Obstructive sleep apnoea syndrome (OSAS) is a common respiratory disorder with devastating consequences for integrative body systems. A picture emerging to illustrate wide-ranging deleterious of disordered breathing during major homeostatic control systems, considerable interest in cardiorespiratory and autonomic morbidity underpinning the development hypertension. The vista bleak when one also considers link between OSAS host other maladies. Exposure chronic intermittent hypoxia (CIH), resulting from repeated obstructions pharyngeal airway, hallmark feature that appears, animal models, drive maintenance several key morbidities. growing evidence now points aberrant plasticity at multiple levels following exposure CIH. Herein, we review experimental data revealing CIH causes: muscle weakness fatigue; impaired motor upper airway; and, discordant rhythm pattern generation. This multifaceted conspiracy creates perfect storm potential exacerbate OSAS-serving establish an inescapable cycle morbidity. Several pharmacological interventions models appear wholly effective preventing calamitous may have application as adjunctive therapies treatment OSAS.