Evaluation of Ketorolac, Ibuprofen, Acetaminophen, and an Acetaminophen‐Codeine Combination in Postoperative Oral Surgery Pain

摘要: Two-hundred six outpatients with postoperative pain after the surgical removal of impacted third molars were randomly assigned on a double-blind basis to receive oral doses ketorolac tromethamine 10 and 20 mg, ibuprofen 400 acetaminophen 600 combination mg plus codeine 60 or placebo. Using self-rating record, subjects rated their its relief hourly for 6 hours medicating. All active medications significantly superior Analgesia was similar mg; however, these treatments alone acetaminophen-codeine combination. The analgesic effect each medication significant by hour 1 persisted 5-6 hours. data suggest plateau in ketorolac's efficacy at 10-mg level. Repeat-dose indicated that day surgery also acetaminophen-codeine. Differences among not when entire period (days 0-6) evaluated. frequency adverse effects medications.