Craving behavioral intervention for internet gaming disorder: remediation of functional connectivity of the ventral striatum.

摘要: Psychobehavioral intervention is an effective treatment of Internet addiction, including gaming disorder (IGD). However, the neural mechanisms underlying its efficacy remain unclear. Cortical-ventral striatum (VS) circuitry a common target psychobehavioral interventions in drug and cortical-VS dysfunction has been reported IGD; hence, primary aim study was to investigate how VS responds IGD. In cross-sectional study, we examined resting-state functional connectivity 74 IGD subjects (IGDs) 41 healthy controls (HCs). follow-up craving behavioral (CBI) subjects, 20 received CBI (CBI+) 16 did not (CBI-). All participants were scanned twice with similar time interval assess effects CBI. showed greater left inferior parietal lobule (lIPL), right frontal gyrus middle gyrus, positive association severity Moreover, compared CBI-, CBI+ significantly decrease VS-lIPL connectivity, along amelioration addiction following intervention. These findings demonstrated that between lIPL, each presumably mediating attentional bias, may be potential biomarker results also suggested non-invasive techniques such as transcranial magnetic or direct current stimulation targeting VS-IPL used disorders.