Clinical and Prognostic Significance of Cell Sensitivity to Chemotherapy Detected in vitro on Treatment Response and Survival of Leukemia Patients.

摘要: Multidrug resistance (MDR) is a major challenge in leukemia treatment. The objective of this study was to identity predictors MDR allow for rapid and economical assessment the efficacy planned antitumor therapy patients. included 113 patients with acute chronic leukemias. Prior therapy, we measured sensitivity tumor cells panel chemotherapeutic drugs, together MDR1 mRNA P-glycoprotein (P-gp) expression as one mechanisms MDR, compared these data response therapy. scales according response, drug cells, P-gp levels, presence unfavorable immunological cytogenetic markers were introduced subsequent correlation analysis. We show that estimated vitro at diagnosis correlates poor chemotherapy usually combined aberrant immature markers, abnormalities, high P-gp. All together, factors indicate prognosis low survival Thus, drugs may have prognostic value individual types leukemia.