4',4''-SUBSTITUTED 3α-(DIPHENYLMETHOXY)TROPANE ANALOGS FOR TREATMENT OF MENTAL DISORDERS
作者： Frank P. Zemlan
DOI:
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摘要: The present invention describes a method for the treatment of attention deficit hyperactivity disorder (ADHD), conduct disorder, alcohol addiction, tobacco nicotine parkinsonim including Parkinson's disease, female and male orgasmic disorders, sexual arousal hypoactive desire disorders characterized by anxiety and/or depression. In this method, therapeutically effective, nontoxid dose 4',4''-substituted 3α-(diphenylmethoxy)tropane analog or pharmaceutically acceptable salt thereof is administered to patient in need such treatment.
lens.org参考文章(36)
Sari Izenwasser, Richard H. Kline, Jonathan L. Katz, Amy Hauck Newman, Andrew C. Allen, 4' and 4', 4"-substituted-3-α-(diphenylmethoxy) tropane analogs as cocaine therapeutics ,(1996)
Elena H. Chartoff, Maria Papadopoulou, Christine Konradi, William A. Carlezon, Dopamine-dependent increases in phosphorylation of cAMP response element binding protein (CREB) during precipitated morphine withdrawal in primary cultures of rat striatum Journal of Neurochemistry. ,vol. 87, pp. 107- 118 ,(2003) , 10.1046/J.1471-4159.2003.01992.X
Jonathan P. Wisor, Seiji Nishino, Ichiro Sora, George H. Uhl, Emmanuel Mignot, Dale M. Edgar, Dopaminergic role in stimulant-induced wakefulness. The Journal of Neuroscience. ,vol. 21, pp. 1787- 1794 ,(2001) , 10.1523/JNEUROSCI.21-05-01787.2001
David J. Brunswick, Jay D. Amsterdam, P. David Mozley, Andrew Newberg, Greater Availability of Brain Dopamine Transporters in Major Depression Shown by [99mTc]TRODAT-1 SPECT Imaging American Journal of Psychiatry. ,vol. 160, pp. 1836- 1841 ,(2003) , 10.1176/APPI.AJP.160.10.1836
Mu-Fa Zou, Theresa Kopajtic, Jonathan L Katz, Sara Wirtz, Joseph B Justice, Amy Hauck Newman, None, Novel tropane-based irreversible ligands for the dopamine transporter. Journal of Medicinal Chemistry. ,vol. 44, pp. 4453- 4461 ,(2001) , 10.1021/JM0101904
PETER S. JENSEN, STEPHEN P. HINSHAW, JAMES M. SWANSON, LAURENCE L. GREENHILL, C. KEITH CONNERS, L. EUGENE ARNOLD, HOWARD B. ABIKOFF, GLEN ELLIOTT, LILY HECHTMAN, BETSY HOZA, JOHN S. MARCH, JEFFREY H. NEWCORN, JOANNE B. SEVERE, BENEDETTO VITIELLO, KAREN WELLS, TIMOTHY WIGAL, Findings from the NIMH Multimodal Treatment Study of ADHD (MTA): Implications and applications for primary care providers. Journal of Developmental and Behavioral Pediatrics. ,vol. 22, pp. 60- 73 ,(2001) , 10.1097/00004703-200102000-00008
Tsuyoshi Kondo, Kazuo Mihara, Akihito Suzuki, Norio Yasui-Furukori, Sunao Kaneko, Combination of dopamine D2 receptor gene polymorphisms as a possible predictor of treatment-resistance to dopamine antagonists in schizophrenic patients Progress in Neuro-Psychopharmacology and Biological Psychiatry. ,vol. 27, pp. 921- 926 ,(2003) , 10.1016/S0278-5846(03)00151-9
Erkki Tupala, Håkan Hall, Tuija Mantere, Pirkko Räsänen, Terttu Särkioja, Jari Tiihonen, Dopamine receptors and transporters in the brain reward circuits of type 1 and 2 alcoholics measured with human whole hemisphere autoradiography NeuroImage. ,vol. 19, pp. 145- 155 ,(2003) , 10.1016/S1053-8119(03)00060-0
Fabrizio Stocchi, Laura Vacca, Alfredo Berardelli, Marco Onofrj, Mario Manfredi, Stefano Ruggieri, Dual dopamine agonist treatment in Parkinson's disease. Journal of Neurology. ,vol. 250, pp. 822- 826 ,(2003) , 10.1007/S00415-003-1086-0
Giuseppe Campiani, Stefania Butini, Francesco Trotta, Caterina Fattorusso, Bruno Catalanotti, Francesca Aiello, Sandra Gemma, Vito Nacci, Ettore Novellino, Jennifer Ann Stark, Alfredo Cagnotto, Elena Fumagalli, Francesco Carnovali, Luigi Cervo, Tiziana Mennini, Synthesis and pharmacological evaluation of potent and highly selective D3 receptor ligands: inhibition of cocaine-seeking behavior and the role of dopamine D3/D2 receptors. Journal of Medicinal Chemistry. ,vol. 46, pp. 3822- 3839 ,(2003) , 10.1021/JM0211220