Benztropine compounds and uses thereof

作者: Jonathan L. Katz , Mu-Fa Zou , Amy Hauck Newman

DOI:

关键词:

摘要: Disclosed are benztropine analogs having the formula (I) in which Ar is a C 6 -C 20 monocyclic aryl group or 10 bicyclic heteroaryl, heterocyclic, arylheterocyclic 2 to 12 carbon atoms and one more heteroatoms selected from consisting of N, O, S, P, any combination thereof; m=1 5; n=1 3; R 1 4 as described specification; pharmaceutically acceptable salt solvate pharmaceutical compositions use thereof, e.g., treating mental disorders.

参考文章(59)
Sari Izenwasser, Richard H. Kline, Jonathan L. Katz, Amy Hauck Newman, Andrew C. Allen, 4' and 4', 4"-substituted-3-α-(diphenylmethoxy) tropane analogs as cocaine therapeutics ,(1996)
Elena H. Chartoff, Maria Papadopoulou, Christine Konradi, William A. Carlezon, Dopamine-dependent increases in phosphorylation of cAMP response element binding protein (CREB) during precipitated morphine withdrawal in primary cultures of rat striatum Journal of Neurochemistry. ,vol. 87, pp. 107- 118 ,(2003) , 10.1046/J.1471-4159.2003.01992.X
Jonathan P. Wisor, Seiji Nishino, Ichiro Sora, George H. Uhl, Emmanuel Mignot, Dale M. Edgar, Dopaminergic role in stimulant-induced wakefulness. The Journal of Neuroscience. ,vol. 21, pp. 1787- 1794 ,(2001) , 10.1523/JNEUROSCI.21-05-01787.2001
Frank Watjen, Jorgen Scheel-Kruger, Peter Moldt, Tropane-derivatives, their preparation and use ,(1997)
David J. Brunswick, Jay D. Amsterdam, P. David Mozley, Andrew Newberg, Greater Availability of Brain Dopamine Transporters in Major Depression Shown by [99mTc]TRODAT-1 SPECT Imaging American Journal of Psychiatry. ,vol. 160, pp. 1836- 1841 ,(2003) , 10.1176/APPI.AJP.160.10.1836
Richard A. Glennon, John J. Salley, Odd S. Steinsland, Sharon Nelson, Synthesis and evaluation of novel alkylpiperazines as potential dopamine antagonists Journal of Medicinal Chemistry. ,vol. 24, pp. 678- 683 ,(1981) , 10.1021/JM00138A007
Satendra Singh, Chemistry, design, and structure-activity relationship of cocaine antagonists. Chemical Reviews. ,vol. 100, pp. 925- 1024 ,(2000) , 10.1021/CR9700538
François Giuliano, Julien Allard, Dopamine and male sexual function. European Urology. ,vol. 40, pp. 601- 608 ,(2001) , 10.1159/000049844