An approach to the mapping of antigens on the cell surface.

摘要: Trlhe antigeniic individuality of the surfaces cells from differenit members a species (genotypic variation) has been an object study time Landsteiner discovered human ABO blood groups in 1900 to present era organ transplantation. Only recently, however, attention directed antigenic different single member (phenotypic diversity), although it comes as no surprise find that cellular differentiation associated with selective gene activation gives rise serologically demonstrable differences cell surface structure. Four five systems alloantigens known occur on thymocytes (Table 1) are limited one or few types. These four have special interest inodels quantitative phenotypic variation within individual, and since they components, presumably relevant organization interdependent populations; is hardly likely such lacking biological significance. Fortunately these antigens-0, Ly-A, Ly-B, TL-as well H-2, exhibit both genotypic (allelic) variability (i.e., "differentiation" "cell-type-specific" antigens), this makes their individual recognition possible. At least additional thymocyte/lymphocyte-specific antigen, mouse-specific lymphocyte antigen (MSLA),4 lacks allelic (being only heteroalntisera) therefore subject restrictions where segregation cannot be used. antigens because constitute physical basis for confronting same inidividual, contrast genotypically determined colifrontinig two populations contrived situation homotransplantation. We answered, can readily answer, usual questions relating any Table 1, namely, "Is particular cell?" "in what quantity?" But we know virtually niothinig about dispositioni