Bioimpedance Analysis for the Characterization of Breast Cancer Cells in Suspension

摘要: The bioimpedance spectroscopy (BIS) technique is potentially a useful tool to differentiate malignancy based on the variation of electrical properties presented by different tissues and cells. cells present variant resistance reactance when excited at frequencies. main purpose this area research use impedance measurements over low-frequency bandwidth ranging from 1 kHz 3 MHz 1) pathological stages cancer under laboratory conditions 2) permit extraction parameters related cellular information for further analysis. This provides evidence form basis measurement level aids potential future development rapid diagnostics biopsy materials. Three cell lines, representing normal breast epithelia cancer, have been measured using standard analyzer driving four-electrode chamber filled with suspensions. We identify specific BIS profile each type determine whether these can be differentiated. In addition, parameters, e.g., intracellular conductivity, membrane capacitance/capacity, characteristic frequency, are extracted equivalent circuit models physical provide details electric signatures analysis pathology.