BRAF mutation predicts for poor outcomes after metastasectomy in patients with metastatic colorectal cancer.
作者： Rona Yaeger , Andrea Cercek , Joanne F. Chou , Brooke E. Sylvester , Nancy E. Kemeny
DOI: 10.1002/CNCR.28729
关键词:
摘要: BACKGROUND BRAF mutations occur in 5% to 11% of patients with metastatic colorectal cancer (mCRC) and have been associated poor prognosis. The current study was undertaken determine the clinicopathologic characteristics, PIK3CA (phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha) mutation frequency, outcomes after metastasectomy BRAF-mutant mCRC. METHODS Data from 1941 consecutive mCRC who underwent KRAS/BRAF testing between 2009 2012 at a single institution were identified identify cases (92 cases). BRAF wild-type 2011 (423 cases) served as control group. RESULTS BRAF-mutated found be significantly older age diagnosis, female sex, right-sided location, poorly differentiated morphology, mucinous histology compared cases. more frequently progressed stage III disease (32% vs 17%; P = .003) among those disease, T4 common (48% 27%; P = .05). co-mutated tumors versus 17% KRAS-mutant (P < .01) 4% BRAF/KRAS Patients BRAF-mutated presented peritoneal involvement (26% 14%; P < 0.01) less liver-limited metastases (41% 63%; P < .01). likely undergo 26% 2 years diagnosis disease; P < .01) lower overall survival metastasectomy. CONCLUSIONS BRAF-mutant is worse clinical outcome. commonly develop metastases, present limited liver, shorter tumors. Cancer 2014;120:2316–2324. © 2014 American Society.
sci-hub.se 参考文章(28)
Yu Imamura, Teppei Morikawa, Xiaoyun Liao, Paul Lochhead, Aya Kuchiba, Mai Yamauchi, Zhi Rong Qian, Reiko Nishihara, Jeffrey A. Meyerhardt, Kevin M. Haigis, Charles S. Fuchs, Shuji Ogino, Specific Mutations in KRAS Codons 12 and 13, and Patient Prognosis in 1075 BRAF Wild-Type Colorectal Cancers Clinical Cancer Research. ,vol. 18, pp. 4753- 4763 ,(2012) , 10.1158/1078-0432.CCR-11-3210
H J N Andreyev, A R Norman, D Cunningham, J Oates, B R Dix, B J Iacopetta, J Young, T Walsh, R Ward, N Hawkins, M Beranek, P Jandik, R Benamouzig, E Jullian, P Laurent-Puig, S Olschwang, O Muller, I Hoffmann, H M Rabes, C Zietz, C Troungos, C Valavanis, S T Yuen, J W C Ho, C T Croke, D P O’Donoghue, W Giaretti, A Rapallo, A Russo, V Bazan, M Tanaka, K Omura, T Azuma, T Ohkusa, T Fujimori, Y Ono, M Pauly, C Faber, R Glaesener, A F P M de Goeij, J W Arends, S N Andersen, T Lövig, J Breivik, G Gaudernack, O P F Clausen, P De Angelis, G I Meling, T O Rognum, R Smith, H-S Goh, A Font, R Rosell, X F Sun, H Zhang, J Benhattar, L Losi, J Q Lee, S T Wang, P A Clarke, S Bell, P Quirke, V J Bubb, J Piris, N R Cruickshank, D Morton, J C Fox, F Al-Mulla, N Lees, C N Hall, D Snary, K Wilkinson, D Dillon, J Costa, V E Pricolo, S D Finkelstein, J S Thebo, A J Senagore, S A Halter, S Wadler, S Malik, K Krtolica, N Urosevic, Kirsten ras mutations in patients with colorectal cancer: the ‘RASCAL II’ study British Journal of Cancer. ,vol. 85, pp. 692- 696 ,(2001) , 10.1054/BJOC.2001.1964
Daniel J Weisenberger, Kimberly D Siegmund, Mihaela Campan, Joanne Young, Tiffany I Long, Mark A Faasse, Gyeong Hoon Kang, Martin Widschwendter, Deborah Weener, Daniel Buchanan, Hoey Koh, Lisa Simms, Melissa Barker, Barbara Leggett, Joan Levine, Myungjin Kim, Amy J French, Stephen N Thibodeau, Jeremy Jass, Robert Haile, Peter W Laird, CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer. Nature Genetics. ,vol. 38, pp. 787- 793 ,(2006) , 10.1038/NG1834
Wade S. Samowitz, Karen Curtin, Mark Leppert, Donna Schaffer, Margaret Robertson, Martha L. Slattery, Relationship of Ki-ras Mutations in Colon Cancers to Tumor Location, Stage, and Survival: A Population-based Study Cancer Epidemiology, Biomarkers & Prevention. ,vol. 9, pp. 1193- 1197 ,(2000)
Donna M Muzny, Matthew N Bainbridge, Kyle Chang, Huyen H Dinh, Jennifer A Drummond, Gerald Fowler, Christie L Kovar, Lora R Lewis, Margaret B Morgan, Irene F Newsham, Jeffrey G Reid, Jireh Santibanez, Eve Shinbrot, Lisa R Trevino, Yuan-Qing Wu, Min Wang, Preethi Gunaratne, Lawrence A Donehower, Chad J Creighton, David A Wheeler, Richard A Gibbs, Michael S Lawrence, Douglas Voet, Rui Jing, Kristian Cibulskis, Andrey Sivachenko, Petar Stojanov, Aaron McKenna, Eric S Lander, Stacey Gabriel, Gad Getz, Li Ding, Robert S Fulton, Daniel C Koboldt, Todd Wylie, Jason Walker, David J Dooling, Lucinda Fulton, Kim D Delehaunty, Catrina C Fronick, Ryan Demeter, Elaine R Mardis, Richard K Wilson, Andy Chu, Hye-Jung E Chun, Andrew J Mungall, Erin Pleasance, A Gordon Robertson, Dominik Stoll, Miruna Balasundaram, Inanc Birol, Yaron SN Butterfield, Eric Chuah, Robin JN Coope, Noreen Dhalla, Ranabir Guin, Carrie Hirst, Martin Hirst, Robert A Holt, Darlene Lee, Haiyan I Li, Michael Mayo, Richard A Moore, Jacqueline E Schein, Jared R Slobodan, Angela Tam, Nina Thiessen, Richard Varhol, Thomas Zeng, Yongjun Zhao, Steven JM Jones, Marco A Marra, Adam J Bass, Alex H Ramos, Gordon Saksena, Andrew D Cherniack, Stephen E Schumacher, Barbara Tabak, Scott L Carter, Nam H Pho, Huy Nguyen, Robert C Onofrio, Andrew Crenshaw, Kristin Ardlie, Rameen Beroukhim, Wendy Winckler, Matthew Meyerson, Alexei Protopopov, Juinhua Zhang, Angela Hadjipanayis, Eunjung Lee, Ruibin Xi, Lixing Yang, Xiaojia Ren, Hailei Zhang, Narayanan Sathiamoorthy, Sachet Shukla, Peng-Chieh Chen, Psalm Haseley, Yonghong Xiao, Semin Lee, Jonathan Seidman, Lynda Chin, Peter J Park, Raju Kucherlapati, J Todd Auman, Katherine A Hoadley, Ying Du, Matthew D Wilkerson, Yan Shi, Christina Liquori, Shaowu Meng, Ling Li, Yidi J Turman, Michael D Topal, Donghui Tan, Scot Waring, Elizabeth Buda, Jesse Walsh, Corbin D Jones, Piotr A Mieczkowski, Darshan Singh, Junyuan Wu, Anisha Gulabani, Peter Dolina, Tom Bodenheimer, Alan P Hoyle, Janae V Simons, Matthew Soloway, Lisle E Mose, Stuart R Jefferys, Saianand Balu, Brian D O’Connor, Jan F Prins, Derek Y Chiang, D Neil Hayes, Charles M Perou, Toshinori Hinoue, Daniel J Weisenberger, Dennis T Maglinte, Fei Pan, Benjamin P Berman, David J Van Den Berg, Hui Shen, Timothy Triche Jr, Stephen B Baylin, Peter W Laird, Michael Noble, Doug Voet, Nils Gehlenborg, Comprehensive molecular characterization of human colon and rectal cancer Nature. ,vol. 487, pp. 330- 337 ,(2012) , 10.1038/NATURE11252
E. Van Cutsem, I. Lang, G. Folprecht, M. Nowacki, C. Barone, I. Shchepotin, J. Maurel, D. Cunningham, I. Celik, C. Kohne, Cetuximab plus FOLFIRI: Final data from the CRYSTAL study on the association of KRAS and BRAF biomarker status with treatment outcome. Journal of Clinical Oncology. ,vol. 28, pp. 3570- 3570 ,(2010) , 10.1200/JCO.2010.28.15_SUPPL.3570
G. I Meling, P Laurent-Puig, B. J Iacopetta, R Glaesener, O. P. F Clausen, F Al-Mulla, W Giaretti, V. J Bubb, A. F. P. M de Goeij, G Gaudernack, T Ohkusa, P Quirke, A Rapallo, N Hawkins, R Rosell, T. O Rognum, S. N Andersen, R Smith, J Costa, R Ward, I Hoffmann, T Fujimori, D Cunningham, D Morton, C. T Croke, J Oates, X. F Sun, S Bell, P. A Clarke, S. T Wang, J Breivik, O Muller, A. R Norman, J. W Arends, M Pauly, D Dillon, H. J. N Andreyev, S. D Finkelstein, A. J Senagore, C. N Hall, K Wilkinson, N Lees, N. R Cruickshank, H. S Goh, D Snary, E Jullian, C Valavanis, L Losi, A Russo, H. M Rabes, J Piris, S Wadler, Y Ono, T Azuma, A Font, C Zietz, M Beranek, J. C Fox, S. A Halter, R Benamouzig, B. R Dix, H Zhang, C Faber, K Omura, V. E Pricolo, C Troungos, K Krtolica, J Benhattar, J. W. C Ho, N. Urosevic, T Lovig, D. P O'Donoghue, J. S Thebo, P De Angelis, J. Q Lee, J Young, Bazan, P Jandik, S Olschwang, S. T Yuen, T Walsh, S Malik, M Tanaka, Kirsten ras mutations in patients with colorectal cancer : the ‘RASCAL II’ study Faculty of Health; Institute of Health and Biomedical Innovation. ,vol. 85, pp. 692- 696 ,(2001)
David R. Cox, Regression Models and Life-Tables Springer Series in Statistics. ,vol. 34, pp. 527- 541 ,(1992) , 10.1007/978-1-4612-4380-9_37
Maria Arcila, Christopher Lau, Khedoudja Nafa, Marc Ladanyi, Detection of KRAS and BRAF Mutations in Colorectal Carcinoma: Roles for High-Sensitivity Locked Nucleic Acid-PCR Sequencing and Broad-Spectrum Mass Spectrometry Genotyping The Journal of Molecular Diagnostics. ,vol. 13, pp. 64- 73 ,(2011) , 10.1016/J.JMOLDX.2010.11.005
L Assersohn, A Norman, D Cunningham, T Benepal, P J Ross, J Oates, Influence of metastatic site as an additional predictor for response and outcome in advanced colorectal carcinoma British Journal of Cancer. ,vol. 79, pp. 1800- 1805 ,(1999) , 10.1038/SJ.BJC.6990287