RAS mutations affect pattern of metastatic spread and increase propensity for brain metastasis in colorectal cancer
作者： Rona Yaeger , Elizabeth Cowell , Joanne F. Chou , Alexandra N. Gewirtz , Laetitia Borsu
DOI: 10.1002/CNCR.29196
关键词:
摘要: BACKGROUND RAS and PIK3CA mutations in metastatic colorectal cancer (mCRC) have been associated with worse survival. We sought to evaluate the impact of RAS on cumulative incidence metastasis potentially curable sites liver lung other such as bone brain. METHODS We performed a computerized search electronic medical record our institution for mCRC cases genotyped or from 2008 2012. Cases were reviewed patient characteristics, survival, site-specific metastasis. RESULTS Among 918 patients identified, 477 wild type, 441 had mutation (394 at KRAS exon 2, 29 3 4, 18 NRAS). was significantly shorter median overall survival (OS) multivariate analysis independently predicted OS (HR, 1.6; P < .01). mutant exhibited higher lung, bone, brain an independent predictor involvement these 1.5, 1.6, 3.7, respectively). occurred 10% 786 genotyped, did not predict exhibit pattern spread. CONCLUSIONS The potential CRC varies presence mutation. is increased metastasis. An understanding this spread may help inform physicians' assessment symptoms mCRC. Cancer 2015;121:1195–1203. © 2014 American Society.
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