Class I PI3K in oncogenic cellular transformation.
作者： L Zhao , P K Vogt
DOI: 10.1038/ONC.2008.244
关键词:
摘要: Class I phosphoinositide 3-kinase (PI3K) is a dimeric enzyme, consisting of a catalytic and a regulatory subunit. The catalytic subunit occurs in four isoforms designated as p110α, p110β…
nature.com
sci-hub.se 参考文章(133)
Lazaros C. Foukas, Caroline A. Beeton, Jorgen Jensen, Wayne A. Phillips, Peter R. Shepherd, Regulation of Phosphoinositide 3-Kinase by Its Intrinsic Serine Kinase Activity In Vivo Molecular and Cellular Biology. ,vol. 24, pp. 966- 975 ,(2004) , 10.1128/MCB.24.3.966-975.2004
Michael E. Pacold, Sabine Suire, Olga Perisic, Samuel Lara-Gonzalez, Colin T. Davis, Edward H. Walker, Phillip T. Hawkins, Len Stephens, John F. Eccleston, Roger L. Williams, Crystal Structure and Functional Analysis of Ras Binding to Its Effector Phosphoinositide 3-Kinase γ Cell. ,vol. 103, pp. 931- 944 ,(2000) , 10.1016/S0092-8674(00)00196-3
Ji Luo, Seth J. Field, Jennifer Y. Lee, Jeffrey A. Engelman, Lewis C. Cantley, The p85 regulatory subunit of phosphoinositide 3-kinase down-regulates IRS-1 signaling via the formation of a sequestration complex. Journal of Cell Biology. ,vol. 170, pp. 455- 464 ,(2005) , 10.1083/JCB.200503088
Christine Bénistant, H Chapuis, Serge Roche, A specific function for phosphatidylinositol 3-kinase α (p85α-p110α) in cell survival and for phosphatidylinositol 3-kinase β (p85α-p110β) in de novo DNA synthesis of human colon carcinoma cells Oncogene. ,vol. 19, pp. 5083- 5090 ,(2000) , 10.1038/SJ.ONC.1203871
Igor Vivanco, Charles L. Sawyers, The phosphatidylinositol 3-Kinase–AKT pathway in human cancer Nature Reviews Cancer. ,vol. 2, pp. 489- 501 ,(2002) , 10.1038/NRC839
Nikolakaki E, Hemelsoet R, Defize Lh, Woodgett, Coffer Pj, Glycogen synthase kinase 3 phosphorylates Jun family members in vitro and negatively regulates their transactivating potential in intact cells. Oncogene. ,vol. 8, pp. 833- 840 ,(1993)
Chuan-Hsiang Huang, Diana Mandelker, Sandra B. Gabelli, L. Mario Amzel, Insights into the oncogenic effects of /PIK3CA/ mutations from the structure of p110α/p85α Cell Cycle. ,vol. 7, pp. 1151- 1156 ,(2008) , 10.4161/CC.7.9.5817
R. Dhand, I. Hiles, G. Panayotou, S. Roche, M.J. Fry, I. Gout, N.F. Totty, O. Truong, P. Vicendo, K. Yonezawa, PI 3-kinase is a dual specificity enzyme: autoregulation by an intrinsic protein-serine kinase activity. The EMBO Journal. ,vol. 13, pp. 522- 533 ,(1994) , 10.1002/J.1460-2075.1994.TB06290.X
Karen C Arden, FoxO: linking new signaling pathways. Molecular Cell. ,vol. 14, pp. 416- 418 ,(2004) , 10.1016/S1097-2765(04)00213-8
P Sassone-Corsi, J Auwerx, R P de Groot, M Bourouis, Negative regulation of Jun/AP-1: conserved function of glycogen synthase kinase 3 and the Drosophila kinase shaggy. Oncogene. ,vol. 8, pp. 841- 847 ,(1993)