The phosphatidylinositol 3-Kinase–AKT pathway in human cancer
作者： Igor Vivanco , Charles L. Sawyers
DOI: 10.1038/NRC839
关键词:
摘要: … the PIP 3 field is AKT, the cellular homologue of the retroviral oncogene v-Akt, which is also … insights into AKT function, with an emphasis on its links to human cancer. AKT encodes a …
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sci-hub.se 参考文章(155)
Alex Toker, Alexandra C. Newton, Akt/Protein Kinase B Is Regulated by Autophosphorylation at the Hypothetical PDK-2 Site Journal of Biological Chemistry. ,vol. 275, pp. 8271- 8274 ,(2000) , 10.1074/JBC.275.12.8271
Antonio Casamayor, Pamela D. Torrance, Takayasu Kobayashi, Jeremy Thorner, Dario R. Alessi, Functional counterparts of mammalian protein kinases PDK1 and SGK in budding yeast Current Biology. ,vol. 9, pp. 186- 197 ,(1999) , 10.1016/S0960-9822(99)80088-8
Julia A. Romashkova, Sergei S. Makarov, NF-κB is a target of AKT in anti-apoptotic PDGF signalling Nature. ,vol. 401, pp. 86- 90 ,(1999) , 10.1038/43474
Allan T van Oosterom, Ian Judson, Jaap Verweij, Sigrid Stroobants, Eugenio Donato di Paola, Sasa Dimitrijevic, Marc Martens, Andrew Webb, Raf Sciot, Martine Van Glabbeke, Sandra Silberman, Ole S Nielsen, Safety and efficacy of imatinib (STI571) in metastatic gastrointestinal stromal tumours: a phase I study. The Lancet. ,vol. 358, pp. 1421- 1423 ,(2001) , 10.1016/S0140-6736(01)06535-7
G.S. Vemuri, S.E. Rittenhouse, WORTMANNIN INHIBITS SERUM-INDUCED ACTIVATION OF PHOSPHOINOSITIDE 3-KINASE AND PROLIFERATION OF CHRF-288 CELLS Biochemical and Biophysical Research Communications. ,vol. 202, pp. 1619- 1623 ,(1994) , 10.1006/BBRC.1994.2118
Jianguo Gu, Masahito Tamura, Roumen Pankov, Erik H.J. Danen, Takahisa Takino, Kazue Matsumoto, Kenneth M. Yamada, Shc and Fak Differentially Regulate Cell Motility and Directionality Modulated by Pten Journal of Cell Biology. ,vol. 146, pp. 389- 404 ,(1999) , 10.1083/JCB.146.2.389
Vuk Stambolic, Akira Suzuki, José Luis de la Pompa, Greg M Brothers, Christine Mirtsos, Takehiko Sasaki, Jurgen Ruland, Josef M Penninger, David P Siderovski, Tak W Mak, Negative Regulation of PKB/Akt-Dependent Cell Survival by the Tumor Suppressor PTEN Cell. ,vol. 95, pp. 29- 39 ,(1998) , 10.1016/S0092-8674(00)81780-8
M.-M. Georgescu, K. H. Kirsch, T. Akagi, T. Shishido, H. Hanafusa, The tumor-suppressor activity of PTEN is regulated by its carboxyl-terminal region Proceedings of the National Academy of Sciences. ,vol. 96, pp. 10182- 10187 ,(1999) , 10.1073/PNAS.96.18.10182
Xiao-Ping Zhou, Oliver Gimm, Heather Hampel, Theodore Niemann, Michael J. Walker, Charis Eng, Epigenetic PTEN Silencing in Malignant Melanomas without PTEN Mutation American Journal of Pathology. ,vol. 157, pp. 1123- 1128 ,(2000) , 10.1016/S0002-9440(10)64627-5
Jaewon Han, Katherine Luby-Phelps, Balaka Das, Xiaodong Shu, Yi Xia, Raymond D Mosteller, U Murali Krishna, John R Falck, Michael A White, Daniel Broek, Role of Substrates and Products of PI 3-kinase in Regulating Activation of Rac-Related Guanosine Triphosphatases by Vav Science. ,vol. 279, pp. 558- 560 ,(1998) , 10.1126/SCIENCE.279.5350.558