Targeting the phosphatidylinositol 3-kinase pathway in airway smooth muscle: rationale and promise.
作者： Vera P Krymskaya
DOI: 10.2165/00063030-200721020-00003
关键词: Signal transduction 、 PI3K/AKT/mTOR pathway 、 TSC1 、 Cell biology 、 P70-S6 Kinase 1 、 Kinase 、 Phosphatidylinositol 、 TSC2 、 Biology 、 Cell growth
摘要: The phosphatidylinositol 3-kinase (PI3K) signaling pathway plays a critical role in regulating cell growth, proliferation, survival, and motility. Structural alterations, e.g. airway remodeling, asthma chronic obstructive pulmonary disease (COPD) are associated with increased smooth muscle (ASM) growth proliferation due to the frequent stimulation of ASM by inflammatory mediators, contractile agonists, factors. PI3K is well established. However, recent discovery tumor suppressor proteins tuberous sclerosis complex 1 (TSC1) TSC2, also known as hamartin tuberin, downstream effectors upstream regulators mammalian target rapamycin (mTOR) S6 kinase (S6K1) shed new light on cascade proliferation. activity TSC1/TSC2 regulated factors, nutrients, energy; thus, serves module for protein translational regulation, cycle progression, size, which key events controlling This article highlights potential contribution PI3K-TSC1/TSC2-mTOR/S6K1 remodeling. Pharmacologic manipulation this could have major impact treatment COPD.
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