作者: Swetansu K Hota , Saurabh K Bhardwaj , Sebastian Deindl , Yuan-chi Lin , Xiaowei Zhuang
DOI: 10.1038/NSMB.2486
关键词:
摘要: The ISWI family of ATP-dependent chromatin remodelers represses transcription by changing nucleosome positions. regulates positioning requiring a minimal length extranucleosomal DNA for moving nucleosomes. ISW2 from Saccharomyces cerevisiae, member the family, has conserved domain called SLIDE (SANT-like domain) that binds to ~19 base pairs edge Loss binding does not perturb ATPase or initial movement inside Not only is required help recruit ISW2, but also interactions with are functionally move