DNA-protein cross-links induced by nickel compounds in intact cultured mammalian cells.

作者: Steven R. Patierno , Max Costa

DOI: 10.1016/S0009-2797(85)80121-6

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摘要: Summary The carcinogenic activity of crystalline NiS has been attributed to phagocytosis and intracellular dissolution the particles yield Ni 2+ which is thought enter nucleus damage DNA. In this study extent type DNA in Chinese hamster ovary CHO cells treated with various nickel compounds was assessed by alkaline elution. Both insoluble (crystalline NiS) soluble (NiCl 2 ) induced single strand breaks protein cross-links. were repaired relatively quickly but DNA-protein cross-links present still accumulating 24 h after exposure nickel. Single breakage occurred at both non-cytotoxic cytotoxic concentrations nickel, however, cross-linking absent when exposed toxic levels. concentration that correlated those metal reversibly inhibited cellular replication.

参考文章(31)
Richard B. Ciccarelli, Karen E. Wetterhahn, Nickel distribution and DNA lesions induced in rat tissues by the carcinogen nickel carbonate. Cancer Research. ,vol. 42, pp. 3544- 3549 ,(1982)
Richard M. Caprioli, Jeanne Bonura, Jeannie Simmons-Hansen, Max Costa, Carlos W. M. Bedrossian, Phagocytosis, Cellular Distribution, and Carcinogenic Activity of Particulate Nickel Compounds in Tissue Culture Cancer Research. ,vol. 41, pp. 2868- 2878 ,(1981)
F W Sunderman, Recent research on nickel carcinogenesis. Environmental Health Perspectives. ,vol. 40, pp. 131- 141 ,(1981) , 10.1289/EHP.8140131
Michael J. Tsapakos, Karen E. Wetterhahn, Thomas H. Hampton, Chromium(VI)-induced DNA Lesions and Chromium Distribution in Rat Kidney, Liver, and Lung Cancer Research. ,vol. 43, pp. 5662- 5667 ,(1983)
Parvathi K. Basrur, John P. W. Gilman, Morphologic and synthetic response of normal and tumor muscle cultures to nickel sulfide. Cancer Research. ,vol. 27, pp. 1168- 1177 ,(1967)
Richard B. Ciccarelli, Karen E. Wetterhahn, Nickel-bound Chromatin, Nucleic Acids, and Nuclear Proteins from Kidney and Liver of Rats Treated with Nickel Carbonate in Vivo Cancer Research. ,vol. 44, pp. 3892- 3897 ,(1984)
F. William Sunderman, Ronald M. Maenza, Patricia R. Alpass, John M. Mitchell, Ivan Damjanov, Peter J. Goldblatt, Carcinogenicity of nickel subsulfide in Fischer rats and Syrian hamsters after administration by various routes. Advances in Experimental Medicine and Biology. ,vol. 91, pp. 57- 67 ,(1978) , 10.1007/978-1-4684-0796-9_4
F.W. Sunderman, B.L.K. Mangold, S.H.Y. Wong, S.K. Shen, M.C. Reid, I. Jansson, High-performance size-exclusion chromatography of 63Ni-constituents in renal cytosol and microsomes from 63NiCl2-treated rats. The Journal of Urology. ,vol. 130, pp. 840- 840 ,(1983) , 10.1016/S0022-5347(17)51519-0
Jeffrey E. Lee, Richard B. Ciccarelli, Karen Wetterhahn Jennette, Solubilization of the carcinogen nickel subsulfide and its interaction with deoxyribonucleic acid and protein. Biochemistry. ,vol. 21, pp. 771- 778 ,(1982) , 10.1021/BI00533A030