作者: Steven R. Patierno , Max Costa
DOI: 10.1016/S0009-2797(85)80121-6
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摘要: Summary The carcinogenic activity of crystalline NiS has been attributed to phagocytosis and intracellular dissolution the particles yield Ni 2+ which is thought enter nucleus damage DNA. In this study extent type DNA in Chinese hamster ovary CHO cells treated with various nickel compounds was assessed by alkaline elution. Both insoluble (crystalline NiS) soluble (NiCl 2 ) induced single strand breaks protein cross-links. were repaired relatively quickly but DNA-protein cross-links present still accumulating 24 h after exposure nickel. Single breakage occurred at both non-cytotoxic cytotoxic concentrations nickel, however, cross-linking absent when exposed toxic levels. concentration that correlated those metal reversibly inhibited cellular replication.