Evolution of proteomic biomarker for chronic liver disease: Promise into reality.
作者： Krishna Sumanth Nallagangula , KN Shashidhar , V Lakshmaiah , Muninarayana
关键词:
摘要: Liver is the vital organ for synthesis of proteins whose concentration in blood reflects liver dysfunction. Variations protein domain can generate clinically significant biomarkers. Biomarker pipeline includes discovery candidates, qualification, verification, assay optimization, and validation. Advances proteomic approach discover biomarker candidates based on "up-or-down" regulation or fold change expression which correlated with disease state. Despite numerous been discovered, only few are useful clinical practice indicates need well-established validation regimen. Hence, main purpose this review to understand development pitfalls. Companion diagnostics provide insights into potential cost-effective diagnosis chronic disease.
aboutscience.eu
sagepub.com参考文章(49)
L. M. Irwig, Constantine A. Gatsonis, D. E. Bruns, J. B. Reitsma, Patrick M. Bossuyt, Vet de H. C. W, P. Glasziou, Drummond Rennie, D. Moher, J. G. Lijmer, The STARD statement for reporting studies of diagnostic accuracy: Explanation and elaboration Artificial Intelligence. ,(2003)
DAVID L Sackett, R BRIAN Haynes, The architecture of diagnostic research BMJ. ,vol. 324, pp. 539- 541 ,(2002) , 10.1136/BMJ.324.7336.539
Szymon Filip, Konstantinos Vougas, Jerome Zoidakis, Agnieszka Latosinska, William Mullen, Goce Spasovski, Harald Mischak, Antonia Vlahou, Joachim Jankowski, Comparison of Depletion Strategies for the Enrichment of Low-Abundance Proteins in Urine PLOS ONE. ,vol. 10, pp. e0133773- ,(2015) , 10.1371/JOURNAL.PONE.0133773
Leigh Anderson, Candidate-based proteomics in the search for biomarkers of cardiovascular disease The Journal of Physiology. ,vol. 563, pp. 23- 60 ,(2005) , 10.1113/JPHYSIOL.2004.080473
Michael A. Gillette, D. R. Mani, Steven A. Carr, Place of pattern in proteomic biomarker discovery. Journal of Proteome Research. ,vol. 4, pp. 1143- 1154 ,(2005) , 10.1021/PR0500962
Thomas Waerner, Dietmar Thurnher, Kurt Krapfenbauer, The role of laboratory medicine in healthcare: quality requirements of immunoassays, standardisation and data management in prospective medicine The Epma Journal. ,vol. 1, pp. 619- 626 ,(2010) , 10.1007/S13167-010-0053-Y
Bevin Gangadharan, Robin Antrobus, David Chittenden, Jan Rossa, Manisha Bapat, Paul Klenerman, Eleanor Barnes, Raymond A. Dwek, Nicole Zitzmann, New approaches for biomarker discovery: the search for liver fibrosis markers in hepatitis C patients. Journal of Proteome Research. ,vol. 10, pp. 2643- 2650 ,(2011) , 10.1021/PR101077C
Amanda G. Paulovich, Jeffrey R. Whiteaker, Andrew N. Hoofnagle, Pei Wang, The interface between biomarker discovery and clinical validation: The tar pit of the protein biomarker pipeline. Proteomics Clinical Applications. ,vol. 2, pp. 1386- 1402 ,(2008) , 10.1002/PRCA.200780174
Catharine Sturgeon, Robert Hill, Glen L. Hortin, Douglas Thompson, Taking a new biomarker into routine use--a perspective from the routine clinical biochemistry laboratory. Proteomics Clinical Applications. ,vol. 4, pp. 892- 903 ,(2010) , 10.1002/PRCA.201000073
Glen L Hortin, Saeed A Jortani, James C Ritchie, Roland Valdes, Daniel W Chan, Proteomics: A New Diagnostic Frontier Clinical Chemistry. ,vol. 52, pp. 1218- 1222 ,(2006) , 10.1373/CLINCHEM.2006.067280