Neural Regulation of Lung Development

摘要: The respiratory system, comprising the lungs, trachea, vasculature, and associated neural tissues, carries out gas exchange essential for terrestrial life. During early embryonic development, lung primordium, originating from ventral foregut endoderm, bifurcates ventrolaterally to form two primary buds. Within these developing buds, mesoderm interacts with endoderm generate various lineages, including airway smooth muscle, pericytes. As buds progressively invade their surroundings characteristic tree-like architecture of an extensive neuronal network develops concomitantly. This will become control breathing relay sensation central nervous system. Here, we summarize what is known about embryogenesis intrinsic extrinsic innervation how it impacts on development. However, precise ontogeny signals by which regulated are, as yet, not fully elucidated.