Applications of stimulated echo correction to multicomponent T2 analysis

摘要: We propose a multicomponent fitting algorithm for multiecho T(2) data which allows correction of distributions in the presence stimulated echoes. Tracking population spins many coherence pathways via iterated method Extended Phase Graph accurate quantification echo magnitudes. The resulting decay curves allow errors due to nonideal refocusing pulses as result inhomogeneities B(1) transmit field. Non-Negative Least Squares is used quantify magnitude components at various values. This method, allowing calculation distribution with simultaneous extraction pulse flip angle, requires no change image acquisition procedures and extra input. Validation by means both simulations vivo shows excellent interscan reproducibility while vastly improving accuracy extracted parameters voxels where poor homogeneity leads angles significantly less than 180°. Most notably, myelin water fraction values these regions are found have increased consistency accuracy.