The Role of Adams in Notch Signaling
作者： Arjan J. Groot , Marc A. Vooijs
DOI: 10.1007/978-1-4614-0899-4_2
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摘要: Regulated intramembrane proteolysis (RIP) is a highly conserved signaling paradigm whereby membrane-bound proteins are cleaved in their transmembrane region and then released into the cytoplasm to act as molecules. In most if not all cases cleavage preceded regulated by membrane proximal step called ‘ectodomain shedding’. Here we will review role of ectodomain shedding RIP NOTCH pathway, cell-cell communication pathway that mediates cell fate decisions during development adult tissues.
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