Effect of selected antiinflammatory agents and other drugs on zymosan, arachidonic acid, PAF and carrageenan induced paw edema in the mouse.
作者： W. Calhoun , J. Chang , R. P. Carlson
DOI: 10.1007/BF01966499
关键词:
摘要: Zymosan, carrageenan, arachidonic acid and platelet activating factor (PAF) were used to induce inflammation (edema) in the paws of mice. Antiinflammatory drugs (e.g., BW755C indomethacin) as well cyproheptadine (mediator antagonist), theophylline (phosphodiesterase inhibitor) guanabenz (α adrenoceptor agonist) showed greatest efficacy carrageenan zymosan models. Nonsteroidal antiinflammatory (NSAIDs) agents greater activity (AA) paw edema model than dual 5-lipoxygenase (LO)/cyclooxygenase (CO) inhibitors. The PAF was insensitive NSAIDs but some with possessing inhibitory 5-LO phenidone, BW755C) mediator antagonist, cyproheptadine. Suramin, a complement inhibitor, expected, active only against zymosan-induced edema. In conclusion, activities 5-LO/CO inhibitors not different zymosan, AA models mouse; however, selectivity for observed model.
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