Disruption of Th17/Treg Balance in the Sputum of Patients With Chronic Obstructive Pulmonary Disease
作者： Haijun Li , Qixiao Liu , Yuanyuan Jiang , Yi Zhang , Wei Xiao
DOI: 10.1097/MAJ.0000000000000447
关键词:
摘要: Abstract Background Amplified inflammation persists in the airways of patients with chronic obstructive pulmonary disease (COPD); however, underlying mechanism is still unclear. Th17/T regulatory cells (Treg) imbalance may exist and contribute to this abnormal inflammation. Methods This study involved 21 COPD, healthy smokers (HS), nonsmokers (HNS). We investigated receptor-related orphan receptor (RORC2) fork-head box P3 (FOXP3) mRNA expression induced sputum by realtime polymerase chain reaction assayed IL-17, IL-10, TGF-β IL-6 enzyme-linked immunosorbent assay. Th17 Treg peripheral blood were analyzed flow cytometry. Results The level FOXP3 both COPD HNS was lower than that HS ( P Copd = 0.017; = 0.009). In contrast, RORC2 markedly higher either or = 0.005; Conclusions A compartmental over exists suggesting a defect antiinflammatory homeostasis COPD.
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