The effect of human antibacterial peptide LL-37 in the pathogenesis of chronic obstructive pulmonary disease.

摘要: Summary Background Previous research has shown that innate immune system was more important than the acquired in pathogenesis of COPD. LL-37 is only human cathelicidin identified so far. As an integral part system, besides antibacterial activity, its chemotactic damage repairing, influencing apoptosis and cytotoxicity are attracting people's attention. The aim present study to evaluate role Methods ELISA immunohistochemistry were applied investigate expression induced sputum lung tissue COPD patients. Bronchial epithelial cell (BEP2D) alveolar (A549) treated with synthesis polypeptide in vitro assess inflammation apoptosis. Results We found increased levels patients associated airflow limitation, health status exercise tolerance expressing intensity both airway district pulmonary alveoli area group significantly compared control group. Through stimulation by CSE LPS, bronchial cell. can promote releasing inflammatory factor IL-8 induce Conclusion This suggested may play be a possible novel therapeutic target