Activation of the c-myc oncogene.

摘要: The cellular proto-oncogenes were first identified as the sequences within DNA of normal cells that homologous to transforming genes acute oncogenic RNA tumor viruses.1 Numerous studies have linked neoplastic transformation genetic changes in these evolutionarily conserved genes. However, function protooncogenes cell growth and differentiation is still largely unknown, but it almost certain will represent important control elements cell. mechanisms by which essential become activated induce abnormal are quite varied, ranging from point mutations2–4 chromosomal translocation5–7 gene amplification.8–10 In some instances, resultant protein altered structure, while others major consequence activating lesion appears be overexpression or deregulation gene. Studies oncogenes promise provide insight not only into process transformation, also fundamental growth.