Neurocognitive performance and serial intravenous subanesthetic ketamine in treatment-resistant depression

摘要: The N-methyl-D-aspartate glutamate receptor antagonist ketamine has demonstrated rapid antidepressant effects in treatment-resistant depression (TRD). However, evaluation of ketamine's neurocognitive aspects TRD started to be explored. This study aims (1) examine baseline performance and change severity depressive symptoms through six infusions, (2) the after completion serial infusions whether changes were associated relapse depression. Six IV 0.5 mg/Kg over 40 min conducted on a Monday-Wednesday-Friday schedule during 12-d period 15 patients with followed by 4-wk observational period. Neurocognitive functioning was assessed using CogState battery at each follow-up visit. Tasks designed test attention, memory (working, visual, verbal), speed processing, set shifting. likelihood response greater among depressed subjects lower attention (F(1,13)=5.59, p=0.034). Significant improvement found scores visual (F(4,33.82)=5.12, p=0.002), simple working (F(4, 24.85)=3.29, p=0.027) complex 32.76)=4.18, p=0.008) last infusion. accounted for symptom. acute effect repeated not subsequent follow-up. Our findings suggest potential predictor apparently lack short-term impairment TRD.