Acute myelogenous leukaemia in children under 2 years--experiences of the West German AML studies BFM-78, -83 and -87. AML-BFM Study Group.
作者： J Harbott , P Heyen , J Ritter , J Vormoor , G Schellong
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摘要: Clinical, morphological, immunological, cytogenetical and prognostic features of 84 children under 2 years age with AML in studies AML-BFM-78, -83 -87 were retrospectively analysed. There was a high incidence acute monoblastic leukaemia (FAB M5) (41 patients--49%) megakaryoblastic M7) (study AML-BFM-87: five patients--13%) this group. Acute associated hepatosplenomegaly, extramedullary organ manifestations chromosomal abnormalities involving 11q23. The probability an 11-year event-free survival all patients the three combined 39% (SD 6%). While rates aged older could be improved AML-BFM-83 compared study overall prognosis consecutive remained unchanged. rate both groups comparable (7 yr-EFS (AML-BFM-83 -87): much less than years--43% 9%), =/much greater years--33% 9%); P 0.5). This also applied to other risk groups. In conclusion, taking into account, no significant differences between or concerning response therapy evaluated.
参考文章(19)
Richard Peto, M. C. Pike, Conservatism of the approximation sigma (O-E)2-E in the logrank test for survival data or tumor incidence data. Biometrics. ,vol. 29, pp. 579- 584 ,(1973) , 10.2307/2529177
U Creutzig, J Ritter, G Schellong, Treatment of acute myelogenous leukemia in children. Medical oncology and tumor pharmacotherapy. ,vol. 2, pp. 17- 25 ,(1985) , 10.1007/BF02934776
Arnold J. Altaian, Clinical features and biological implications of acute mixed lineage (hybrid) leukemias. Journal of Pediatric Hematology Oncology. ,vol. 12, pp. 123- 133 ,(1990) , 10.1097/00043426-199022000-00001
Philip J. Darbyshire, John H. F. Smith, Anthony Oakhill, Martin G. Mott, Monocytic leukemia in infancy. A review of eight children Cancer. ,vol. 56, pp. 1584- 1589 ,(1985) , 10.1002/1097-0142(19851001)56:7<1584::AID-CNCR2820560720>3.0.CO;2-L
Andreas Hirt, Annette Ridolfi Luethy, Brigitta Mueller, Edouard Gugler, Hans P. Wagner, Acute megakaryoblastic leukemia in children identified by immunological marker studies. Journal of Pediatric Hematology Oncology. ,vol. 12, pp. 27- 33 ,(1990) , 10.1097/00043426-199021000-00006
J. Ritter, U. Creutzig, H. J. Riehm, W. Brandeis, V. Gerein, G. Prindull, M. Rister, G. Schellong, Improved Treatment Results in Childhood Acute Myelogenous Leukemia: An Update of the German Cooperative Study AML-BFM-78 Modern Trends in Human Leukemia VI New Results in Clinical and Biological Research Including Pediatric Oncology. ,vol. 65, pp. 82- 83 ,(1985) , 10.1007/978-3-642-70385-0_20
S. O. Lie, Acute myelogenous leukaemia in children European Journal of Pediatrics. ,vol. 148, pp. 382- 388 ,(1989) , 10.1007/BF00595892
Chin-to Fong, Garrett M. Brodeur, Down's syndrome and leukemia: Epidemiology, genetics, cytogenetics and mechanisms of leukemogenesis☆ Cancer Genetics and Cytogenetics. ,vol. 28, pp. 55- 76 ,(1987) , 10.1016/0165-4608(87)90354-2
JOHN M. BENNETT, Criteria for the Diagnosis of Acute Leukemia of Megakaryocyte Lineage (M7) Annals of Internal Medicine. ,vol. 103, pp. 460- 462 ,(1985) , 10.7326/0003-4819-103-3-460
M. Peeters, A. Poon, Down syndrome and leukemia: unusual clinical aspects and unexpected methotrexate sensitivity European Journal of Pediatrics. ,vol. 146, pp. 416- 422 ,(1987) , 10.1007/BF00444952