摘要: Nervous systems are built on synaptic connections, and our understanding of these complex compartments has deepened over the past quarter century as diverse fields genetics, molecular biology, physiology, biochemistry each made significant in-roads into function. On presynaptic side, an evolutionarily conserved core fusion apparatus constructed from a handful proteins emerged, with Unc13 serving hub that coordinates nearly every aspect transmission. This review briefly highlights recent studies aspects function including roles in SNARE assembly quality control, release site building, calcium channel proximity, short-term plasticity.
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