Translocator Protein (TSPO) in Breast Cancer

摘要: Several molecular and cellular markers are currently used as prognostic indicators for diagnosis therapeutic intervention of breast cancer. Although some these have helped clinicians provide an earlier (or prognosis), they failed to adequate information about the mechanisms responsible different stages tumor malignancy so that more effective anticancer therapies can be developed. Recently translocator protein (TSPO), formerly known peripheral benzodiazepine receptor (PBR), has received attention a potential target drug development. It is well-conserved protein, located at outer-inner mitochondrial membrane contact sites, expressed in almost all tissues, although level expression varies. TSPO closely associated with 32 kDa voltage-dependent anion channel (VDAC) 30 adenine nucleotide translocase (ANT), considered form core mitochondria multiprotein complex [named permeability transition pore (MPTP)] plays role apoptotic cell death. As major steroid biosynthesis, particularly high organs involved steroidogenesis such adrenals, testes, ovaries, placenta, prostate, colon, kidney, cardiovascular system. well over-expressed highly aggressive tumors, especially those breast, correlates advancing this malignancy. expression, nuclear localization, TSPO-mediated cholesterol transport into nucleus cancer proliferation phenotype expression. Hence, it biomarker stage-dependent In addition, proliferation, invasion migration appears decreased when treated doses ligand PK-11195, compound may represent agent control progression. Control development by consumption dietary soy been linked down-regulation angiogenic signaling molecules. This chapter provides insight rational novel therapeutics