Risk factors for fatal and nonfatal reactions to subcutaneous immunotherapy : National surveillance study on allergen immunotherapy (2008–2013)
作者： Tolly G. Epstein , Gary M. Liss , Karen Murphy-Berendts , David I. Bernstein
DOI: 10.1016/J.ANAI.2016.02.001
关键词:
摘要: Abstract Background In 2008, an annual surveillance study of systemic reactions (SRs) from subcutaneous immunotherapy (SCIT) injections was initiated in North America. Objective To define the incidence SRs to SCIT. Methods From 2008 2013, 27% 51% American Academy Allergy, Asthma, and Immunology College members completed survey SCIT-related varying severity. 2012 data were collected regarding with off-label sublingual (SLIT), selection patients asthma for SCIT, strategies dose adjustment during pollen seasons. Results gathered on 28.9 million injection visits, including 344,480 2013. Since a total 2 confirmed fatalities directly reported that occurred under care allergists. Two additional nonallergists. The rate SCIT remained stable, occurring 1.9% patients, 0.08% 0.02% experiencing grade 3 4 SRs. 1.4% receiving SLIT, 0.03% There no SLIT-related or fatalities. Practices never administered uncontrolled (Asthma Control Test score P Conclusions fatality rates may be decreasing, but continued vigilance modifiable risk factors, careful patient selection, is needed. Dose seasons highly sensitive reduce risks. Potential SLIT exists.
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